1.1 Neurons were treated with a drug which immediately and permanently blocked the Na+ - K+ ATPase pump.State the changes that are likely to take place in the resting membrane potential
1. Immediately
2. over a period of 20 minutes
1.2 Explain the changes that you have stated in 1.1 on a physiological basis.
Answer
1.1
- Immediately no change
- Over a period of 20 minutes - resting membrane potential reduced
1.2
When neurons are at non conducting state inside the cell negativly charge and out side the positivly charged this differences is -70mv this is called RMP.This differnace is maintained by K+, Na+ leakage across membrane and active transport of 3 Na+ ion out side and 2 K+ ion in side the cell using energy ( Na+ - K+ ATPase Pump ).When ,Na+ - K+ ATPase Pump blocked by drug more more Na + accumulate inside the nerve cell and negativity inside cell membrane reduced . it results reduced resting membrane potential
Labels: Excitable tissue, Excitable tissue MCQs, Excitable tissue SEQs, Physiology SEQ