MCQs: Insulin dependent glucose uptake occurs in

Answer

a. Muscle

Discussion

Glucose transporters

Glucose enters into cells by facilitated diffuson and secondary active transport . The glucose transporters ( GLUTs ) responsible for facillited diffusion of glucose into cells. there are seven different glucose transporters, named GLUTs 1 - 7 . GLUT 4 found in muscle and adipose tissue and get stimulated by insulin.

The sodium-dependent glucose transporters( SGLT 1 , SGLT 2 ) responsible for the secondary active transport of glucose in the intestine and renal tubules .

Summary of glucose transport

	Function	Major Sites of Expression
Secondary active transport (Na-glucose cotransport)
SGLT 1	Absorption of glucose	Small intestine, renal tubules
SGLT 2	Absorption of glucose	Renal tubules
Facilitated diffusion
GLUT 1	Basal glucose uptake	Placenta, blood-brain barrier, brain, red cells, kidneys, colon, many other organs
GLUT 2	B-cell glucose sensor; transport out of intestinal and renal epithelial cells	B cells of islets, liver, epithelial cells of small intestine, kidneys
GLUT 3	Basal glucose uptake	Brain, placenta, kidneys, many other organs
GLUT 4	Insulin-stimulated glucose uptake	Skeletal and cardiac muscle, adipose tissue, other tissues
GLUT 5	Fructose transport	Jejunum, sperm
GLUT 6	None	Pseudogene
GLUT 7	Glucose 6-phosphate ransporter in endoplasmic reticulum	Liver, ? other tissues

source ganong's review of medical physiology

Insulin dependent glucose uptake occurs in

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