Renal Physiology SEQs
1.1 List the factors which affect glomerular filtration rate (40)
1.2. Explain how water in the glomerular filtrate is handled by
1.2.1. The proximal tubule (20)
1.2.2. The loop of Henle (20)
1.2.3. The collecting duct (20)
2.1. Explain the role of following in the reflex control of micturition
2.1.1. The parasympathetic nerve supply (20)
2.1.2. The pudendal nerves (20)
2.2. A patient who had hypoventilation due to acute pneumonia had a blood pH of 7.33 & a plasma bicarbonate of 34.0meq/L (normal range 24.0 to 28.0 meq/L)
2.2.1. What kind of acid: base disturbance is indicated by the above findings? (20)
2.2.2. How does the kidney compensate for this? (20)
2.3. A certain substance had a plasma clearance of 70ml/min. what does this value indicate regarding the handling of the substance by the kidney? (20)
3.1 Define plasma clearance (20 marks)
3.2 A substance had a plasma clearance of 185 ml/min. What does this value indicate regarding the renal handling of this substance? (20 marks)
3.2.1The early distal tubule of the kidney is hypotonic to blood plasma. Explain this. (20 marks)
3. 2.2 Aldosterone secretion was found to increase in animals that have been deprived of salt in their diet. Explain the physiological significance of this statement
4. A 60 year old man complained to a GP that he had to get up at night to pass urine. The GP found him to be having polyuria and glycosuria due to diabetes mellitus and he was started on Tolbutamide (sulfonylurea). He was referred to a physician for further investigations, which revealed him to be having chronic renal failure due to diabetes mellitus.
4.1. What is the type of diabetes mellitus you would expect to see in this patient? (10marks)
4.1.1. From the above information, give two reasons for your answer in 1.1 (20marks)
4.1.2. Explain the basis for following findings in this patient: (70marks)
4.1.2.1. Polyuria
4.1.2.2. Glycosuria
Labels: Physiology SEQ, Renal, Renal SEQs