1.Drug a showing first order kinetics has a half life of 8 hours and a volume of distribution of 3 L
The drug A
A. Is likely to be a water soluble drug
B. Could be propanalol
C.Takes 24 hrs for 87.5 % of an intravenous bolus dose to be eliminate
D.Is likely to cause neurological complication in overdose
E. Is more likely to be metabolized in the liver than to be excreted unchanged in the urine
2.Regarding a drug with Pka 3.0
A.it is readily absorb in stomach
B.It has large volume f distribution
C.Its excretion is enhanced by urine alkalinization
D.It has good CNS penetration
E.Its absorption gets impaired by co administration of a proton pump inhibitor
3.The following are example for topical therapy
A. Trans-dermal glyceryl trinitrate for angina
B. Inhaled beclomethasone
C.Oral vancomycin for pesudomembrane colitis
D.Oral neomycin for hepatic enchephalopathy
E. Oral flucanazole for esophageal candidiasis
4.Anti- Pseudomonal antibiotics include
A. Ciprofloxacin
B. Clarithromycin
C. Vancomycin
D. Ceftazidime
E. Ticacillin
5. Hepatic P- 450 induced by
A.Sulphonalure
B.Carbamezapine
C.Rifampin
D.Cimetadine
E.Omeprazole
Answer
1. T,F,T,F,F
2.T,F,T,F,T
3.F,T,F,F,T
4 T,F,F,T,T
5.T,T,T,F,F